ritlecitinib will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Ritlecitinib inhibits CYP3A4 substrates; coadministration raises AUC and peak plasma concentration delicate substrates, which may improve risk of adverse reactions.Keep track of Intently (two)primidone will… Read More